
Integrative Immunology (i2)
description
The Integrative Immunology team (i2) is engaged in the global analysis and modelling of the complexity of the immune system. We have developed a systems immunology approach of T cell differentiation and dynamics in physiological and pathological situations relying on statistical and dynamic computer modelling. Integration of multi-scale and multi-level data (flow cytometry, transcriptome, proteome, repertoire) allows modelling the dynamics and repertoire diversity of lymphocyte populations as well as analysing their gene expression. Our aim is to design an "immuno-physiome" of the immune system considered as a complex system, focussing on the T lymphocyte populations. The perspective of this work is to describe, predict and explain the puzzling complex T cells dynamics throughout differentiation and selection of T cell populations from thymus to peripheral organs in physiological conditions through ageing, as well as immunological perturbations or diseases, associated to molecular and T cell repertoire diversity alterations.
Fields of interest
Contact info
Address: i2 - Integrative Immunology, Inserm UMRS 959 - Sorbonne Université, Bâtiment CERVI, CHU Pitié-Salpêtrière, 83 boulevard de l'HôpitalCity: Paris
Postal code: 75013
Region: Ile-de-France
Telephone: +33 1 42 17 65 11
Fax: +33 1 42 17 65 17
Website: http://www.i3-immuno.fr
Top Publications
- Ritvo PG, Saadawi A, Barennes P, Quiniou V, Chaara W, El Soufi K, Bonnet B, Six A, Shugay M, Mariotti-Ferrandiz E, Klatzmann D
High-resolution repertoire analysis reveals a major bystander activation of Tfh and Tfr cells
Proc Natl Acad Sci USA. 2018, 115(38):9604-9609 - Chaara W, Gonzalez A, Florez L, Klatzmann D, Mariotti-Ferrandiz E, Six A
Representativeness and robustness of TCR repertoire diversity assessment by high-throughput sequencing
Frontiers in Immunology 2018, 9:1038 - Thomas-Vaslin V
Understanding and modeling the complexity of the immune system, In: First complex systems digital campus world E-conference 2015 Springer Proceedings in Complexity
Springer, Cham 2017, 261-270 - Pitoiset F, Vazquez T, Levacher B, Nehar-Belaid D, Dérian N, Vigneron J, Klatzmann D, Bellier B
Retrovirus-based virus-like particle immunogenicity and its modulation by Toll-like receptor activation
J Virol 2017, 91(21):e01230-17