Personal Statement
Prof. of Immunology, Chief of Biotherapy, Coordinator of the Inflammatory-Immunopathology-Immunotherapy department and Coordinator of the Clinical Investigation Center in Biotherapy at Pierre and Marie Curie Medical School and Pitié-Salpêtrière hospital.
Research Statement
My practice has always been devoted to translational research in Immunology.
- I contributed to the discovery of HIV and then revealed its preferential tropism and cytopathic effect - the first indication that HIV causes AIDS - which I later explained by showing that CD4 is the prime HIV receptor
- I developed the concept of suicide genes from preclinical studies to clinical trials
- I developed a vaccine platform that is currently translated in a CMV vaccine
- I investigated the role of Tregs in autoimmune diseases, maternal-fetal tolerance and cancer, and conceived Treg-based therapeutic approaches, notably using low-dose IL2
- I introduced Systems Immunology approach in these translational efforts
My current efforts are now in translational systems immunology, with a main focus on Tregs and their TCRs. My 3 (overambitious) main goals are:
- to contrast the role of Tregs in autoimmune diseases, cancer and maternal-fetal tolerance
- to elucidate the TCR repertoire of Tregs in health and (some) diseases
- to validate low-dose IL2 in (some) autoimmune diseases
Affiliations
Fields of Interest
My field of interests are in Science, Literature, Visual Arts and more generally everything that intrigues and stimulates my brain.
Publications (selection)
- Barennes P, Quiniou V, Shugay M, Egorov ES, Davydov AN, Chudakov DM, Uddin I, Ismail M, Oakes T, Chain B, Eugster A, Kashofer K, Rainer PP, Darko S, Ransier A, Douek DC, Klatzmann D, Mariotti-Ferrandiz E
Benchmarking of T cell receptor repertoire profiling methods reveals large systematic biases
Nature Biotechnology, 2020 - Ritvo PG, Saadawi A, Barennes P, Quiniou V, Chaara W, El Soufi K, Bonnet B, Six A, Shugay M, Mariotti-Ferrandiz E, Klatzmann D
High-resolution repertoire analysis reveals a major bystander activation of Tfh and Tfr cells
Proc Natl Acad Sci USA. 2018, 115(38):9604-9609 - Lorenzon R, Mariotti-Ferrandiz E, Aheng C, Ribet C, Toumi F, Pitoiset F, Chaara W, Derian N, Johanet C, Drakos I, Harris S, Amselem S, Berenbaum F, Benveniste O, Bodaghi B, Cacoub P, Grateau G, Amouyal C, Hartemann A, Saadoun D, Sellam J, Seksik P...
Clinical and multi-omics cross-phenotyping of patients with autoimmune and autoinflammatory diseases: the observational TRANSIMMUNOM protocol
BMJ OPEN 2018, 8(8):E021037 - Chaara W, Gonzalez A, Florez L, Klatzmann D, Mariotti-Ferrandiz E, Six A
Representativeness and robustness of TCR repertoire diversity assessment by high-throughput sequencing
Frontiers in Immunology 2018, 9:1038 - Pitoiset F, Vazquez T, Levacher B, Nehar-Belaid D, Dérian N, Vigneron J, Klatzmann D, Bellier B
Retrovirus-based virus-like particle immunogenicity and its modulation by Toll-like receptor activation
J Virol 2017, 91(21):e01230-17